The antitumor effect of a novel angiogenesis inhibitor (an octahydronaphthalene derivative) targeting both VEGF receptor and NF-κB pathway. [electronic resource]
- International journal of cancer Jul 2012
- 310-21 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-0215
10.1002/ijc.26356 doi
Angiogenesis Inhibitors--pharmacology Animals Cell Line Cell Movement Cell Proliferation Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors Human Umbilical Vein Endothelial Cells Humans I-kappa B Proteins--metabolism Intercellular Adhesion Molecule-1--biosynthesis Interleukin-1beta--antagonists & inhibitors Male Mice Mice, Inbred BALB C Mice, Inbred C57BL NF-KappaB Inhibitor alpha NF-kappa B--metabolism Naphthols--pharmacology Neovascularization, Physiologic--drug effects Oncogene Protein v-akt--metabolism Phosphorylation Pyridines--pharmacology Receptors, Vascular Endothelial Growth Factor--metabolism Signal Transduction--drug effects Transcription Factor RelA--antagonists & inhibitors Tumor Necrosis Factor-alpha--antagonists & inhibitors