TY - GEN AU - Soltysinska,Ewa AU - Thiele,Stefanie AU - Olesen,Søren Peter AU - Osadchii,Oleg E TI - Chronic sympathetic activation promotes downregulation of β-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction SN - 1432-2013 PY - 2012///0105 KW - Adrenergic beta-Agonists KW - pharmacology KW - Animals KW - Calcium Channels, L-Type KW - metabolism KW - Colforsin KW - Cyclic AMP KW - Down-Regulation KW - drug effects KW - G-Protein-Coupled Receptor Kinase 2 KW - biosynthesis KW - GTP-Binding Protein alpha Subunits, Gs KW - Guinea Pigs KW - Isoproterenol KW - KCNQ1 Potassium Channel KW - Male KW - Myocardial Contraction KW - Myocardium KW - Receptors, Adrenergic, beta KW - Refractory Period, Electrophysiological KW - Signal Transduction KW - Systole KW - Ventricular Remodeling N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1007/s00424-011-1005-7 ER -