The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. [electronic resource]
- The Journal of clinical investigation Sep 2011
- 3635-44 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1558-8238
10.1172/JCI45790 doi
Alleles Autoantibodies--immunology Autoimmune Diseases--genetics Autoimmunity--immunology B-Lymphocytes--cytology Genetic Predisposition to Disease Humans Isoenzymes--genetics Polymorphism, Single Nucleotide Protein Tyrosine Phosphatase, Non-Receptor Type 22--genetics Risk Factors Self Tolerance--genetics