TY  - GEN
AU  - Sayahi,Halimah
AU  - Zimhony,Oren
AU  - Jacobs,William R
AU  - Shekhtman,Alexander
AU  - Welch,John T
TI  - Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase I
SN  - 1464-3405
PY  - 2011///1122
KW  - Bacterial Proteins
KW  - antagonists & inhibitors
KW  - Binding Sites
KW  - drug effects
KW  - Binding, Competitive
KW  - Crystallography, X-Ray
KW  - Enzyme Inhibitors
KW  - chemistry
KW  - Fatty Acid Synthases
KW  - Magnetic Resonance Spectroscopy
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Mycobacterium tuberculosis
KW  - enzymology
KW  - NADP
KW  - Pyrazinamide
KW  - analogs & derivatives
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1016/j.bmcl.2011.06.055
ER  -