cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity. [electronic resource]
- Cellular signalling Dec 2011
- 1927-35 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1873-3913
10.1016/j.cellsig.2011.06.025 doi
1-Methyl-3-isobutylxanthine--pharmacology Adaptor Proteins, Signal Transducing Adenylate Kinase--metabolism Amino Acids--pharmacology Animals Carrier Proteins--metabolism Cell Cycle Proteins Cell Line Colforsin--pharmacology Cyclic AMP--chemistry Eukaryotic Initiation Factors Gene Deletion Gene Knockout Techniques Humans Insulin--pharmacology Mechanistic Target of Rapamycin Complex 1 Mice Monomeric GTP-Binding Proteins--genetics Multiprotein Complexes Neuropeptides--genetics Phosphodiesterase Inhibitors--pharmacology Phosphoproteins--metabolism Phosphorylation Protein Binding Protein Kinases--metabolism Proteins--agonists Ras Homolog Enriched in Brain Protein Recombinant Proteins--genetics Ribosomal Protein S6 Kinases, 90-kDa--metabolism Signal Transduction TOR Serine-Threonine Kinases Transcription Factors--agonists Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins--genetics