TY - GEN AU - Possemato,Richard AU - Marks,Kevin M AU - Shaul,Yoav D AU - Pacold,Michael E AU - Kim,Dohoon AU - Birsoy,Kıvanç AU - Sethumadhavan,Shalini AU - Woo,Hin-Koon AU - Jang,Hyun G AU - Jha,Abhishek K AU - Chen,Walter W AU - Barrett,Francesca G AU - Stransky,Nicolas AU - Tsun,Zhi-Yang AU - Cowley,Glenn S AU - Barretina,Jordi AU - Kalaany,Nada Y AU - Hsu,Peggy P AU - Ottina,Kathleen AU - Chan,Albert M AU - Yuan,Bingbing AU - Garraway,Levi A AU - Root,David E AU - Mino-Kenudson,Mari AU - Brachtel,Elena F AU - Driggers,Edward M AU - Sabatini,David M TI - Functional genomics reveal that the serine synthesis pathway is essential in breast cancer SN - 1476-4687 PY - 2011///0928 KW - Animals KW - Biomarkers, Tumor KW - metabolism KW - Breast Neoplasms KW - enzymology KW - Cell Line, Tumor KW - Cell Proliferation KW - Citric Acid Cycle KW - physiology KW - Gene Expression Regulation, Enzymologic KW - Gene Expression Regulation, Neoplastic KW - Genomics KW - Glutamic Acid KW - Humans KW - Ketoglutaric Acids KW - Melanoma KW - Mice KW - Neoplasm Transplantation KW - Phosphoglycerate Dehydrogenase KW - genetics KW - RNA Interference KW - Serine KW - biosynthesis N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/nature10350 ER -