TY - GEN AU - Caffrey,Daniel R AU - Zhao,Juan AU - Song,Zhili AU - Schaffer,Michael E AU - Haney,Steven A AU - Subramanian,Romesh R AU - Seymour,Albert B AU - Hughes,Jason D TI - siRNA off-target effects can be reduced at concentrations that match their individual potency SN - 1932-6203 PY - 2011///1227 KW - 3' Untranslated Regions KW - genetics KW - Base Sequence KW - Caspase 3 KW - metabolism KW - Caspase 7 KW - Cell Line, Tumor KW - Cell Proliferation KW - Gene Expression Profiling KW - Hexokinase KW - Humans KW - Oligonucleotide Array Sequence Analysis KW - RNA Interference KW - RNA, Messenger KW - RNA, Small Interfering KW - Reverse Transcriptase Polymerase Chain Reaction KW - STAT3 Transcription Factor N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1371/journal.pone.0021503 ER -