TY  - GEN
AU  - Liu,Lichuan
AU  - Halladay,Jason S
AU  - Shin,Young
AU  - Wong,Susan
AU  - Coraggio,Melis
AU  - La,Hank
AU  - Baumgardner,Matthew
AU  - Le,Hoa
AU  - Gopaul,Sashi
AU  - Boggs,Jason
AU  - Kuebler,Peter
AU  - Davis,John C
AU  - Liao,X Charlene
AU  - Lubach,Joseph W
AU  - Deese,Alan
AU  - Sowell,C Gregory
AU  - Currie,Kevin S
AU  - Young,Wendy B
AU  - Khojasteh,S Cyrus
AU  - Hop,Cornelis E C A
AU  - Wong,Harvey
TI  - Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor
SN  - 1521-009X
PY  - 2012///0329
KW  - Agammaglobulinaemia Tyrosine Kinase
KW  - Amides
KW  - metabolism
KW  - Animals
KW  - Cells, Cultured
KW  - Clinical Trials, Phase I as Topic
KW  - Dogs
KW  - Double-Blind Method
KW  - Female
KW  - Hepatocytes
KW  - Humans
KW  - Hydrolysis
KW  - Macaca fascicularis
KW  - Male
KW  - Mice
KW  - Microsomes, Liver
KW  - Protein Kinase Inhibitors
KW  - Protein-Tyrosine Kinases
KW  - antagonists & inhibitors
KW  - Pyrimidinones
KW  - Randomized Controlled Trials as Topic
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Species Specificity
KW  - Thiophenes
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/dmd.111.040840
ER  -