Liu, Lichuan <br/><br/>
Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Oct 2011 
 - 1840-9 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.111.040840  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Agammaglobulinaemia Tyrosine Kinase<br/>Amides--metabolism<br/>Animals<br/>Cells, Cultured<br/>Clinical Trials, Phase I as Topic<br/>Dogs<br/>Double-Blind Method<br/>Female<br/>Hepatocytes--metabolism<br/>Humans<br/>Hydrolysis<br/>Macaca fascicularis<br/>Male<br/>Mice<br/>Microsomes, Liver--metabolism<br/>Protein Kinase Inhibitors--metabolism<br/>Protein-Tyrosine Kinases--antagonists & inhibitors<br/>Pyrimidinones--metabolism<br/>Randomized Controlled Trials as Topic<br/>Rats<br/>Rats, Sprague-Dawley<br/>Species Specificity<br/>Thiophenes--metabolism