TY  - GEN
AU  - Levin,Bruce
AU  - Thompson,John L P
AU  - Chakraborty,Bibhas
AU  - Levy,Gilberto
AU  - MacArthur,Robert
AU  - Haley,E Clarke
TI  - Statistical aspects of the TNK-S2B trial of tenecteplase versus alteplase in acute ischemic stroke: an efficient, dose-adaptive, seamless phase II/III design
SN  - 1740-7753
PY  - 2012///0223
KW  - Acute Disease
KW  - Clinical Trials, Phase II as Topic
KW  - methods
KW  - Clinical Trials, Phase III as Topic
KW  - Computer Simulation
KW  - Dose-Response Relationship, Drug
KW  - Double-Blind Method
KW  - Drug Approval
KW  - Early Termination of Clinical Trials
KW  - Fibrinolytic Agents
KW  - administration & dosage
KW  - Humans
KW  - Multicenter Studies as Topic
KW  - Patient Selection
KW  - Randomized Controlled Trials as Topic
KW  - Research Design
KW  - Selection Bias
KW  - Stroke
KW  - drug therapy
KW  - Tenecteplase
KW  - Tissue Plasminogen Activator
N1  - Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1177/1740774511410582
ER  -