Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ). [electronic resource]
- Journal of neuroinflammation Jul 2011
- 79 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1742-2094
10.1186/1742-2094-8-79 doi
Amyloid beta-Peptides--pharmacology Animals Cell Line Cytokines--metabolism Female Interleukin-1beta--metabolism Ligands Lipopolysaccharides--pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Microglia--cytology Mitogen-Activated Protein Kinase 14--antagonists & inhibitors Peptide Fragments--pharmacology Pyridazines--metabolism Pyrimidines--metabolism Rats Rats, Sprague-Dawley Signal Transduction--physiology Toll-Like Receptors--agonists Tumor Necrosis Factor-alpha--metabolism Up-Regulation--drug effects