TY  - GEN
AU  - Kalgutkar,Amit S
AU  - Tugnait,Meera
AU  - Zhu,Tong
AU  - Kimoto,Emi
AU  - Miao,Zhuang
AU  - Mascitti,Vincent
AU  - Yang,Xin
AU  - Tan,Beijing
AU  - Walsky,Robert L
AU  - Chupka,Jonathan
AU  - Feng,Bo
AU  - Robinson,Ralph P
TI  - Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus
SN  - 1521-009X
PY  - 2012///0227
KW  - Administration, Oral
KW  - Adult
KW  - Animals
KW  - Biological Availability
KW  - Biotransformation
KW  - Bridged Bicyclo Compounds, Heterocyclic
KW  - pharmacokinetics
KW  - Caco-2 Cells
KW  - Cross-Over Studies
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Cytochrome P-450 Enzyme System
KW  - metabolism
KW  - Dogs
KW  - Drug Evaluation, Preclinical
KW  - Female
KW  - Glucuronosyltransferase
KW  - HEK293 Cells
KW  - Hepatocytes
KW  - drug effects
KW  - Humans
KW  - Intestinal Absorption
KW  - Male
KW  - Microsomes, Liver
KW  - enzymology
KW  - Middle Aged
KW  - Protein Binding
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Sodium-Glucose Transport Proteins
KW  - antagonists & inhibitors
KW  - Young Adult
N1  - Publication Type: Journal Article; Randomized Controlled Trial
UR  - https://doi.org/10.1124/dmd.111.040675
ER  -