Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. [electronic resource]
- Neoplasia (New York, N.Y.) Jun 2011
- 516-25 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5586
10.1593/neo.11122 doi
Animals Animals, Newborn Antineoplastic Agents--pharmacology Bone Neoplasms--metabolism Cell Line, Tumor Cell Proliferation--drug effects Dose-Response Relationship, Drug Epithelial-Mesenchymal Transition--drug effects Gene Expression Regulation, Neoplastic--drug effects Humans Immunohistochemistry Integrin alphaV--metabolism Male Mice Mice, Inbred BALB C Mice, Nude Neoplastic Stem Cells--drug effects Neovascularization, Pathologic--prevention & control Osteoclasts--drug effects Prostatic Neoplasms--drug therapy Reverse Transcriptase Polymerase Chain Reaction Tumor Burden--drug effects Tumor Microenvironment--drug effects Twist-Related Protein 1--genetics Xenograft Model Antitumor Assays