The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells. [electronic resource]
- Mitochondrion Sep 2011
- 707-15 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1872-8278
10.1016/j.mito.2011.05.013 doi
Adenosine Triphosphate--biosynthesis Animals Antioxidants--pharmacology Cells, Cultured Chaperonin 60--metabolism Chromans--pharmacology Citrate (si)-Synthase--metabolism Cytochromes b5--metabolism Dopaminergic Neurons--drug effects Electron Transport Complex I--metabolism Electron Transport Complex II--metabolism Electron Transport Complex IV--metabolism Enzyme Assays Humans Intracellular Signaling Peptides and Proteins--deficiency Mice Mice, Knockout Mitochondria--enzymology Mitochondrial Proteins--metabolism Oncogene Proteins--deficiency Oxidative Stress Oxygen Consumption Parkinsonian Disorders--drug therapy Protein Deglycase DJ-1 Protein Kinases--deficiency