Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits. [electronic resource]
- Biochemistry Jul 2011
- 6508-17 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1520-4995
10.1021/bi200708w doi
Animals Catalytic Domain Enzyme Stability Glutamate-Cysteine Ligase--chemistry Glutathione--biosynthesis Homozygote Humans Kinetics Mice Models, Biological Mutant Proteins--metabolism Mutation--genetics Protein Binding Protein Structure, Secondary Recombinant Proteins--metabolism Saccharomyces cerevisiae--metabolism Structural Homology, Protein Temperature