TY - GEN AU - Mayes,Patrick A AU - Dolloff,Nathan G AU - Daniel,Colin J AU - Liu,J Judy AU - Hart,Lori S AU - Kuribayashi,Kageaki AU - Allen,Joshua E AU - Jee,David I H AU - Dorsey,Jay F AU - Liu,Yingqiu Y AU - Dicker,David T AU - Brown,J Martin AU - Furth,Emma E AU - Klein,Peter S AU - Sears,Rosalie C AU - El-Deiry,Wafik S TI - Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1 SN - 1538-7445 PY - 2011///1003 KW - Adenocarcinoma KW - blood supply KW - Angiogenesis Inhibitors KW - pharmacology KW - Animals KW - Antineoplastic Agents KW - Apoptosis KW - drug effects KW - CDC2 Protein Kinase KW - antagonists & inhibitors KW - Camptothecin KW - analogs & derivatives KW - Cell Hypoxia KW - Cell Line, Tumor KW - Colonic Neoplasms KW - Drug Synergism KW - Fluorouracil KW - Gene Expression Regulation, Neoplastic KW - Glycogen Synthase Kinase 3 KW - Glycogen Synthase Kinase 3 beta KW - Humans KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Inhibitor of Apoptosis Proteins KW - physiology KW - Irinotecan KW - Mice KW - Mice, Nude KW - Neoplasm Proteins KW - Protein Kinase Inhibitors KW - Proto-Oncogene Proteins c-myb KW - Pyrimidines KW - RNA, Small Interfering KW - Recombinant Proteins KW - TNF-Related Apoptosis-Inducing Ligand KW - Thiazoles KW - Tumor Suppressor Protein p53 KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/0008-5472.CAN-11-1383 ER -