TY  - GEN
AU  - Wang,Haishan
AU  - Yu,Niefang
AU  - Chen,Dizhong
AU  - Lee,Ken Chi Lik
AU  - Lye,Pek Ling
AU  - Chang,Joyce Wei Wei
AU  - Deng,Weiping
AU  - Ng,Melvin Chi Yeh
AU  - Lu,Ting
AU  - Khoo,Mui Ling
AU  - Poulsen,Anders
AU  - Sangthongpitag,Kanda
AU  - Wu,Xiaofeng
AU  - Hu,Changyong
AU  - Goh,Kee Chuan
AU  - Wang,Xukun
AU  - Fang,Lijuan
AU  - Goh,Kay Lin
AU  - Khng,Hwee Hoon
AU  - Goh,Siok Kun
AU  - Yeo,Pauline
AU  - Liu,Xin
AU  - Bonday,Zahid
AU  - Wood,Jeanette M
AU  - Dymock,Brian W
AU  - Kantharaj,Ethirajulu
AU  - Sun,Eric T
TI  - Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile
SN  - 1520-4804
PY  - 2011///0923
KW  - Administration, Oral
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Benzimidazoles
KW  - Biological Availability
KW  - Cell Line, Tumor
KW  - Dogs
KW  - Drug Screening Assays, Antitumor
KW  - Female
KW  - Histone Deacetylase 1
KW  - antagonists & inhibitors
KW  - Histone Deacetylase Inhibitors
KW  - Humans
KW  - Isoenzymes
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Mice, Nude
KW  - Microsomes, Liver
KW  - metabolism
KW  - Neoplasm Transplantation
KW  - Quantitative Structure-Activity Relationship
KW  - Rats
KW  - Rats, Wistar
KW  - Stereoisomerism
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm2003552
ER  -