Nishimura, Nobuko <br/><br/>
Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives.  [electronic resource] 

 -  Journal of medicinal chemistry  Jul 2011 
 - 4735-51 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm200386s  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Biological Availability<br/>Crystallography, X-Ray<br/>Humans<br/>In Vitro Techniques<br/>Liver--blood supply<br/>Male<br/>Mice<br/>Models, Molecular<br/>Phosphatidylinositol 3-Kinases--chemistry<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Phosphorylation<br/>Protein Binding<br/>Protein Conformation<br/>Quinolines--chemical synthesis<br/>Quinoxalines--chemical synthesis<br/>Rats<br/>Rats, Sprague-Dawley<br/>Structure-Activity Relationship<br/>TOR Serine-Threonine Kinases--antagonists & inhibitors<br/>Xenograft Model Antitumor Assays