TY  - GEN
AU  - Furman,Phillip A
AU  - Murakami,Eisuke
AU  - Niu,Congrong
AU  - Lam,Angela M
AU  - Espiritu,Christine
AU  - Bansal,Shalini
AU  - Bao,Haiying
AU  - Tolstykh,Tatiana
AU  - Micolochick Steuer,Holly
AU  - Keilman,Meg
AU  - Zennou,Veronique
AU  - Bourne,Nigel
AU  - Veselenak,Ronald L
AU  - Chang,Wonsuk
AU  - Ross,Bruce S
AU  - Du,Jinfa
AU  - Otto,Michael J
AU  - Sofia,Michael J
TI  - Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661
SN  - 1872-9096
PY  - 2011///1109
KW  - Antiviral Agents
KW  - pharmacology
KW  - Biotransformation
KW  - Cathepsin A
KW  - metabolism
KW  - Chromatography, High Pressure Liquid
KW  - Cloning, Molecular
KW  - Drug Evaluation, Preclinical
KW  - Guanosine Monophosphate
KW  - analogs & derivatives
KW  - Guanylate Kinases
KW  - Hep G2 Cells
KW  - Hepacivirus
KW  - drug effects
KW  - Hepatocytes
KW  - Humans
KW  - Lactic Acid
KW  - Luciferases
KW  - Microbial Sensitivity Tests
KW  - Mitochondria
KW  - Mutation
KW  - Nerve Tissue Proteins
KW  - Phenol
KW  - Phosphorylation
KW  - Prodrugs
KW  - chemistry
KW  - Replicon
KW  - Viral Nonstructural Proteins
KW  - antagonists & inhibitors
KW  - Virus Replication
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.antiviral.2011.05.003
ER  -