Furman, Phillip A <br/><br/>
Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.  [electronic resource] 

 -  Antiviral research  Aug 2011 
 - 120-32 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1872-9096 
<br/><br/><label>Standard No.: </label>10.1016/j.antiviral.2011.05.003  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antiviral Agents--pharmacology<br/>Biotransformation<br/>Cathepsin A--metabolism<br/>Chromatography, High Pressure Liquid<br/>Cloning, Molecular<br/>Drug Evaluation, Preclinical<br/>Guanosine Monophosphate--analogs & derivatives<br/>Guanylate Kinases--metabolism<br/>Hep G2 Cells<br/>Hepacivirus--drug effects<br/>Hepatocytes--drug effects<br/>Humans<br/>Lactic Acid--metabolism<br/>Luciferases--metabolism<br/>Microbial Sensitivity Tests<br/>Mitochondria--drug effects<br/>Mutation<br/>Nerve Tissue Proteins--metabolism<br/>Phenol--metabolism<br/>Phosphorylation<br/>Prodrugs--chemistry<br/>Replicon<br/>Viral Nonstructural Proteins--antagonists & inhibitors<br/>Virus Replication--drug effects