Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells. [electronic resource]
- Journal of translational medicine May 2011
- 71 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1479-5876
10.1186/1479-5876-9-71 doi
Adolescent Adult Aged Antigens, CD34--metabolism Apoptosis--drug effects Caspase 3--metabolism Cell Line, Tumor Cell Proliferation--drug effects Curcumin--pharmacology Daunorubicin--pharmacology Drug Resistance, Neoplasm--drug effects Drug Synergism Female G1 Phase--drug effects Gene Expression Regulation, Leukemic--drug effects Humans Leukemia, Myeloid, Acute--enzymology Male Membrane Potential, Mitochondrial--drug effects Middle Aged Poly(ADP-ribose) Polymerases--metabolism Protein Processing, Post-Translational--drug effects Proto-Oncogene Proteins c-bcl-2--genetics RNA, Messenger--genetics RNA, Small Interfering--metabolism S Phase--drug effects