Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer. [electronic resource]
- Cancer prevention research (Philadelphia, Pa.) Jul 2011
- 1041-51 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1940-6215
10.1158/1940-6207.CAPR-11-0023 doi
Animals Antibiotics, Antineoplastic--therapeutic use Blotting, Western Body Weight--drug effects Caloric Restriction Carcinoma, Pancreatic Ductal--metabolism Combined Modality Therapy Disease Models, Animal Glucose--metabolism Glucose Tolerance Test Glycogen Synthase Kinase 3--metabolism Glycogen Synthase Kinase 3 beta Immunoenzyme Techniques Insulin-Like Growth Factor I--metabolism Male Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases--metabolism Pancreatic Neoplasms--metabolism Phosphorylation--drug effects Proto-Oncogene Proteins c-akt--metabolism Ribosomal Protein S6 Kinases, 70-kDa--metabolism STAT3 Transcription Factor--metabolism Sirolimus--therapeutic use TOR Serine-Threonine Kinases--metabolism Tumor Cells, Cultured