TY  - GEN
AU  - Bungay,Peter J
AU  - Tweedy,Sarah
AU  - Howe,David C
AU  - Gibson,Karl R
AU  - Jones,Hannah M
AU  - Mount,Natalie M
TI  - Preclinical and clinical pharmacokinetics of PF-02413873, a nonsteroidal progesterone receptor antagonist
SN  - 1521-009X
PY  - 2011///1209
KW  - Animals
KW  - Biotransformation
KW  - Caco-2 Cells
KW  - Chromatography, High Pressure Liquid
KW  - Dogs
KW  - Dose-Response Relationship, Drug
KW  - Double-Blind Method
KW  - Drug Evaluation, Preclinical
KW  - Hepatocytes
KW  - enzymology
KW  - Humans
KW  - Injections, Intravenous
KW  - Intestinal Secretions
KW  - chemistry
KW  - Male
KW  - Microsomes, Liver
KW  - Models, Biological
KW  - Molecular Structure
KW  - Predictive Value of Tests
KW  - Prospective Studies
KW  - Protein Binding
KW  - Pyrazoles
KW  - blood
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptors, Progesterone
KW  - antagonists & inhibitors
KW  - Solubility
KW  - Species Specificity
KW  - Sulfones
KW  - Tandem Mass Spectrometry
N1  - Publication Type: Journal Article; Randomized Controlled Trial
UR  - https://doi.org/10.1124/dmd.110.037234
ER  -