TY - GEN AU - Tanabe,Katsuya AU - Liu,Yang AU - Hasan,Syed D AU - Martinez,Sara C AU - Cras-Méneur,Corentin AU - Welling,Cris M AU - Bernal-Mizrachi,Ernesto AU - Tanizawa,Yukio AU - Rhodes,Christopher J AU - Zmuda,Erik AU - Hai,Tsonwin AU - Abumrad,Nada A AU - Permutt,M Alan TI - Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation SN - 1932-6203 PY - 2011///0823 KW - Activating Transcription Factor 3 KW - metabolism KW - Animals KW - Apoptosis KW - drug effects KW - Cell Line KW - Endoplasmic Reticulum KW - Enzyme Activation KW - Glucose KW - pharmacology KW - Glycogen Synthase Kinase 3 KW - antagonists & inhibitors KW - Glycogen Synthase Kinase 3 beta KW - Insulin KW - Insulin Receptor Substrate Proteins KW - Insulin-Secreting Cells KW - cytology KW - JNK Mitogen-Activated Protein Kinases KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Palmitic Acid KW - Signal Transduction KW - Sterol Regulatory Element Binding Protein 1 KW - Stress, Physiological N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1371/journal.pone.0018146 ER -