Tanabe, Katsuya

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation. [electronic resource] - PloS one Apr 2011 - e18146 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0018146 doi


Activating Transcription Factor 3--metabolism
Animals
Apoptosis--drug effects
Cell Line
Endoplasmic Reticulum--drug effects
Enzyme Activation--drug effects
Glucose--pharmacology
Glycogen Synthase Kinase 3--antagonists & inhibitors
Glycogen Synthase Kinase 3 beta
Insulin--metabolism
Insulin Receptor Substrate Proteins--metabolism
Insulin-Secreting Cells--cytology
JNK Mitogen-Activated Protein Kinases--metabolism
Male
Mice
Mice, Inbred C57BL
Palmitic Acid--pharmacology
Signal Transduction--drug effects
Sterol Regulatory Element Binding Protein 1--metabolism
Stress, Physiological--drug effects