Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation. [electronic resource]
- PloS one Apr 2011
- e18146 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0018146 doi
Activating Transcription Factor 3--metabolism Animals Apoptosis--drug effects Cell Line Endoplasmic Reticulum--drug effects Enzyme Activation--drug effects Glucose--pharmacology Glycogen Synthase Kinase 3--antagonists & inhibitors Glycogen Synthase Kinase 3 beta Insulin--metabolism Insulin Receptor Substrate Proteins--metabolism Insulin-Secreting Cells--cytology JNK Mitogen-Activated Protein Kinases--metabolism Male Mice Mice, Inbred C57BL Palmitic Acid--pharmacology Signal Transduction--drug effects Sterol Regulatory Element Binding Protein 1--metabolism Stress, Physiological--drug effects