TY - GEN AU - Bekaii-Saab,Tanios AU - Phelps,Mitch A AU - Li,Xiaobai AU - Saji,Motoyasu AU - Goff,Laura AU - Kauh,John Sae Wook AU - O'Neil,Bert H AU - Balsom,Stephanie AU - Balint,Catherine AU - Liersemann,Ryan AU - Vasko,Vasily V AU - Bloomston,Mark AU - Marsh,William AU - Doyle,L Austin AU - Ellison,Gilian AU - Grever,Michael AU - Ringel,Matthew D AU - Villalona-Calero,Miguel A TI - Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers SN - 1527-7755 PY - 2011///0812 KW - Adult KW - Aged KW - Benzimidazoles KW - adverse effects KW - Biliary Tract Neoplasms KW - drug therapy KW - Extracellular Signal-Regulated MAP Kinases KW - metabolism KW - Female KW - Humans KW - MAP Kinase Kinase 1 KW - antagonists & inhibitors KW - MAP Kinase Kinase 2 KW - Male KW - Middle Aged KW - Mutation KW - Neoplasm Metastasis KW - Phosphorylation KW - Proto-Oncogene Proteins KW - genetics KW - Proto-Oncogene Proteins B-raf KW - Proto-Oncogene Proteins c-akt KW - Proto-Oncogene Proteins p21(ras) KW - ras Proteins N1 - Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural UR - https://doi.org/10.1200/JCO.2010.33.9473 ER -