The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens. [electronic resource]
- Disease models & mechanisms Jul 2011
- 484-95 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1754-8411
10.1242/dmm.006593 doi
Activin Receptors, Type I--metabolism Aging--pathology Animals Apoptosis Biomarkers--metabolism Bone Morphogenetic Protein Receptors--metabolism Cataract--prevention & control Cell Cycle Cell Differentiation Cell Proliferation Epithelial Cells--metabolism Eye Neoplasms--metabolism Humans Lens, Crystalline--metabolism Mice Mice, Knockout Models, Biological Phosphorylation Phosphoserine--metabolism Posterior Capsule of the Lens--metabolism Tumor Suppressor Protein p53--genetics