Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity. [electronic resource]
- Breast cancer research : BCR Apr 2011
- R43 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1465-542X
10.1186/bcr2865 doi
Antineoplastic Agents, Hormonal--pharmacology Biomarkers, Tumor Breast Neoplasms--drug therapy Cell Line, Tumor Cell Proliferation Class I Phosphatidylinositol 3-Kinases Down-Regulation Drug Resistance, Neoplasm--genetics Estrogen Receptor beta--genetics Female Gene Expression Regulation, Neoplastic Humans Neuregulin-1--metabolism PTEN Phosphohydrolase--genetics Phosphatidylinositol 3-Kinases--genetics Proto-Oncogene Mas Proto-Oncogene Proteins c-akt--metabolism Receptor, ErbB-2--genetics Receptor, ErbB-3--genetics Signal Transduction Tamoxifen--pharmacology Up-Regulation