TY - GEN AU - Kulkarni,Suhasini AU - Sitaru,Cassian AU - Jakus,Zoltan AU - Anderson,Karen E AU - Damoulakis,George AU - Davidson,Keith AU - Hirose,Misa AU - Juss,Jatinder AU - Oxley,David AU - Chessa,Tamara A M AU - Ramadani,Faruk AU - Guillou,Herve AU - Segonds-Pichon,Anne AU - Fritsch,Anja AU - Jarvis,Gavin E AU - Okkenhaug,Klaus AU - Ludwig,Ralf AU - Zillikens,Detlef AU - Mocsai,Attila AU - Vanhaesebroeck,Bart AU - Stephens,Len R AU - Hawkins,Phillip T TI - PI3Kβ plays a critical role in neutrophil activation by immune complexes SN - 1937-9145 PY - 2011///0801 KW - Animals KW - Antigen-Antibody Complex KW - immunology KW - B-Lymphocytes KW - Blotting, Western KW - CD2 Antigens KW - genetics KW - Class Ia Phosphatidylinositol 3-Kinase KW - Enzyme Inhibitors KW - pharmacology KW - Female KW - Flow Cytometry KW - Gene Rearrangement, B-Lymphocyte KW - Immunoglobulin Heavy Chains KW - Immunoglobulin Joining Region KW - Immunoglobulin Variable Region KW - In Situ Hybridization, Fluorescence KW - Male KW - Mice KW - Mice, Knockout KW - Mice, Transgenic KW - Neutrophil Activation KW - Neutrophils KW - Phosphoinositide-3 Kinase Inhibitors KW - Reactive Oxygen Species KW - metabolism KW - Receptors, IgG KW - Receptors, Leukotriene B4 KW - Signal Transduction KW - drug effects N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1126/scisignal.2001617 ER -