Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). [electronic resource]
- Journal of medicinal chemistry May 2011
- 3331-47 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm200070e doi
Adaptor Proteins, Signal Transducing--physiology Animals CHO Cells Catalytic Domain Cricetinae Cricetulus Crystallography, X-Ray Cyclic Nucleotide Phosphodiesterases, Type 4--chemistry Isoenzymes--antagonists & inhibitors Models, Molecular Phosphodiesterase 4 Inhibitors--chemistry Pyridines--chemistry Rolipram--chemistry Sequestosome-1 Protein Spiro Compounds--chemistry Stereoisomerism Structure-Activity Relationship Xanthines--chemistry