Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection. [electronic resource]
- The Journal of biological chemistry May 2011
- 18890-902 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1083-351X
10.1074/jbc.M110.206110 doi
Acquired Immunodeficiency Syndrome--drug therapy Antimicrobial Cationic Peptides--biosynthesis Apoptosis Regulatory Proteins--metabolism Autophagy--drug effects Autophagy-Related Protein 12 Autophagy-Related Protein 5 Autophagy-Related Protein 7 Beclin-1 Cholecalciferol Dose-Response Relationship, Drug HIV-1--physiology Humans Macrophages Membrane Proteins--metabolism Microtubule-Associated Proteins--metabolism Phosphatidylinositol 3-Kinases--metabolism RNA Interference--drug effects Small Ubiquitin-Related Modifier Proteins--metabolism Ubiquitin-Activating Enzymes--metabolism Virus Replication--drug effects Vitamins--pharmacology Cathelicidins