TY - GEN AU - Foti,Robert S AU - Rock,Dan A AU - Pearson,Josh T AU - Wahlstrom,Jan L AU - Wienkers,Larry C TI - Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction SN - 1521-009X PY - 2011///1107 KW - Chromatography, High Pressure Liquid KW - Cytochrome P-450 CYP3A KW - Cytochrome P-450 CYP3A Inhibitors KW - Enzyme Inhibitors KW - pharmacology KW - Heme KW - metabolism KW - Humans KW - Hydrolysis KW - Mass Spectrometry KW - Mibefradil KW - Spectrophotometry, Ultraviolet N1 - Publication Type: Journal Article UR - https://doi.org/10.1124/dmd.111.038505 ER -