LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. [electronic resource]
- Blood May 2011
- 5532-40 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1528-0020
10.1182/blood-2010-11-318675 doi
Adoptive Transfer Animals Antigens, CD--genetics Antigens, Surface--genetics Apoptosis Regulatory Proteins--deficiency B7-1 Antigen--genetics B7-H1 Antigen Bone Marrow Transplantation--immunology CD4-Positive T-Lymphocytes--immunology CD40 Ligand--antagonists & inhibitors CD8-Positive T-Lymphocytes--immunology CTLA-4 Antigen Female Immune Tolerance Membrane Glycoproteins--deficiency Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Models, Immunological Peptides--deficiency Programmed Cell Death 1 Ligand 2 Protein Programmed Cell Death 1 Receptor Signal Transduction--immunology Transforming Growth Factor beta--immunology Transplantation, Homologous Lymphocyte Activation Gene 3 Protein