An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. [electronic resource]
- Blood May 2011
- 5362-71 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1528-0020
10.1182/blood-2011-01-331041 doi
Amino Acid Substitution Animals Base Sequence Bone Marrow Transplantation DNA Primers--genetics Embryonic Stem Cells--cytology Ethylnitrosourea Female Genes, Recessive Hematopoiesis--genetics Homozygote Inositol Polyphosphate 5-Phosphatases Interleukin-6--biosynthesis Macrophage Activation--genetics Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Mutagenesis Mutation, Missense Phenotype Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases--deficiency Protein Isoforms--deficiency Signal Transduction