Xie, Fang <br/><br/>
The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Jun 2011 
 - 947-51 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.110.037895  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antithyroid Agents--pharmacokinetics<br/>Aryl Hydrocarbon Hydroxylases--genetics<br/>Cytochrome P-450 CYP2A6<br/>Cytochrome P450 Family 2<br/>Liver--drug effects<br/>Metabolic Clearance Rate<br/>Methimazole--pharmacokinetics<br/>Mice<br/>Mice, Inbred C57BL<br/>Mice, Knockout<br/>NADPH-Ferrihemoprotein Reductase--genetics<br/>Olfactory Mucosa--drug effects<br/>Organ Specificity