TY  - GEN
AU  - Yap,Timothy A
AU  - Olmos,David
AU  - Brunetto,Andre T
AU  - Tunariu,Nina
AU  - Barriuso,Jorge
AU  - Riisnaes,Ruth
AU  - Pope,Lorna
AU  - Clark,Jeremy
AU  - Futreal,Andrew
AU  - Germuska,Michael
AU  - Collins,David
AU  - deSouza,Nandita M
AU  - Leach,Martin O
AU  - Savage,Ronald E
AU  - Waghorne,Carol
AU  - Chai,Feng
AU  - Garmey,Edward
AU  - Schwartz,Brian
AU  - Kaye,Stan B
AU  - de Bono,Johann S
TI  - Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies
SN  - 1527-7755
PY  - 2011///0527
KW  - Adolescent
KW  - Adult
KW  - Aged
KW  - Angiogenesis Inhibitors
KW  - adverse effects
KW  - Apoptosis
KW  - drug effects
KW  - Aryl Hydrocarbon Hydroxylases
KW  - genetics
KW  - Biopsy
KW  - Cytochrome P-450 CYP2C19
KW  - Endothelial Cells
KW  - England
KW  - Female
KW  - Focal Adhesion Kinase 1
KW  - metabolism
KW  - Humans
KW  - In Situ Nick-End Labeling
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Maximum Tolerated Dose
KW  - Middle Aged
KW  - Neoplasms
KW  - blood supply
KW  - Neoplastic Cells, Circulating
KW  - Neovascularization, Pathologic
KW  - prevention & control
KW  - Phosphorylation
KW  - Polymorphism, Single Nucleotide
KW  - Protein Kinase Inhibitors
KW  - Proto-Oncogene Proteins c-met
KW  - antagonists & inhibitors
KW  - Pyrrolidinones
KW  - Quinolines
KW  - Receptors, Growth Factor
KW  - Signal Transduction
KW  - Treatment Outcome
KW  - Young Adult
N1  - Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1200/JCO.2010.31.0367
ER  -