Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts. [electronic resource]
- Cardiovascular research Jul 2011
- 80-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1755-3245
10.1093/cvr/cvr067 doi
Analysis of Variance Angiotensin II--administration & dosage Angiotensin II Type 1 Receptor Blockers--pharmacology Animals Cell Adhesion Molecules--genetics Cells, Cultured Cyclic AMP Response Element-Binding Protein--metabolism DNA-Binding Proteins--metabolism Fibroblasts--drug effects Fibrosis Guanine Nucleotide Exchange Factors--metabolism Infusions, Subcutaneous Losartan--pharmacology Male Mitogen-Activated Protein Kinase 1--antagonists & inhibitors Mitogen-Activated Protein Kinase 3--antagonists & inhibitors Myocardium--enzymology Phosphorylation Protein Kinase Inhibitors--pharmacology RNA Interference RNA, Messenger--metabolism Rats Rats, Sprague-Dawley Signal Transduction Smad2 Protein--metabolism Smad3 Protein--metabolism Time Factors Transfection Transforming Growth Factor beta1--metabolism Up-Regulation p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors ras Proteins--genetics