Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system. [electronic resource]
- The Journal of biological chemistry May 2011
- 16546-54 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1083-351X
10.1074/jbc.M110.215319 doi
Adenosine Triphosphatases--chemistry Cell Culture Techniques--methods Cell Line Chemistry, Pharmaceutical--methods Green Fluorescent Proteins--chemistry HeLa Cells Humans Inhibitory Concentration 50 Nuclear Proteins--chemistry Proteasome Endopeptidase Complex--chemistry Protein Structure, Tertiary Proteins--chemistry RNA, Small Interfering--metabolism Technology, Pharmaceutical--methods Ubiquitin--chemistry