TY  - GEN
AU  - Medina,Jesús R
AU  - Becker,Christopher J
AU  - Blackledge,Charles W
AU  - Duquenne,Celine
AU  - Feng,Yanhong
AU  - Grant,Seth W
AU  - Heerding,Dirk
AU  - Li,William H
AU  - Miller,William H
AU  - Romeril,Stuart P
AU  - Scherzer,Daryl
AU  - Shu,Arthur
AU  - Bobko,Mark A
AU  - Chadderton,Antony R
AU  - Dumble,Melissa
AU  - Gardiner,Christine M
AU  - Gilbert,Seth
AU  - Liu,Qi
AU  - Rabindran,Sridhar K
AU  - Sudakin,Valery
AU  - Xiang,Hong
AU  - Brady,Pat G
AU  - Campobasso,Nino
AU  - Ward,Paris
AU  - Axten,Jeffrey M
TI  - Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors
SN  - 1520-4804
PY  - 2011///0617
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Cell Line, Tumor
KW  - Crystallography, X-Ray
KW  - Drug Screening Assays, Antitumor
KW  - Indazoles
KW  - Mice
KW  - Mice, SCID
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Morpholines
KW  - Neoplasm Transplantation
KW  - Phosphorylation
KW  - Piperidines
KW  - Protein Binding
KW  - Protein Serine-Threonine Kinases
KW  - antagonists & inhibitors
KW  - Pyrimidines
KW  - Pyruvate Dehydrogenase Acetyl-Transferring Kinase
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Transplantation, Heterologous
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm101527u
ER  -