Medina, Jesús R <br/><br/>
Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.  [electronic resource] 

 -  Journal of medicinal chemistry  Mar 2011 
 - 1871-95 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm101527u  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemical synthesis<br/>Cell Line, Tumor<br/>Crystallography, X-Ray<br/>Drug Screening Assays, Antitumor<br/>Indazoles--chemical synthesis<br/>Mice<br/>Mice, SCID<br/>Models, Molecular<br/>Molecular Structure<br/>Morpholines--chemical synthesis<br/>Neoplasm Transplantation<br/>Phosphorylation<br/>Piperidines--chemical synthesis<br/>Protein Binding<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Pyrimidines--chemical synthesis<br/>Pyruvate Dehydrogenase Acetyl-Transferring Kinase<br/>Stereoisomerism<br/>Structure-Activity Relationship<br/>Transplantation, Heterologous