TY  - GEN
AU  - LoRusso,Patricia M
AU  - Rudin,Charles M
AU  - Reddy,Josina C
AU  - Tibes,Raoul
AU  - Weiss,Glen J
AU  - Borad,Mitesh J
AU  - Hann,Christine L
AU  - Brahmer,Julie R
AU  - Chang,Ilsung
AU  - Darbonne,Walter C
AU  - Graham,Richard A
AU  - Zerivitz,Kenn L
AU  - Low,Jennifer A
AU  - Von Hoff,Daniel D
TI  - Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors
SN  - 1557-3265
PY  - 2011///0930
KW  - Abdominal Pain
KW  - chemically induced
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Anilides
KW  - adverse effects
KW  - Dose-Response Relationship, Drug
KW  - Drug Resistance, Neoplasm
KW  - Fatigue
KW  - Female
KW  - Gene Expression Regulation, Neoplastic
KW  - drug effects
KW  - Hedgehog Proteins
KW  - antagonists & inhibitors
KW  - Humans
KW  - Hyponatremia
KW  - Male
KW  - Middle Aged
KW  - Neoplasm Metastasis
KW  - Neoplasm Staging
KW  - Neoplasms
KW  - drug therapy
KW  - Pyridines
KW  - Reverse Transcriptase Polymerase Chain Reaction
KW  - Signal Transduction
KW  - Transcription Factors
KW  - genetics
KW  - Treatment Outcome
KW  - Zinc Finger Protein GLI1
N1  - Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/1078-0432.CCR-10-2745
ER  -