Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. [electronic resource]
- Human molecular genetics May 2011
- 1738-50 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1460-2083
10.1093/hmg/ddr049 doi
Active Transport, Cell Nucleus Animals Cell Line Cell Nucleus--genetics Disease Models, Animal Drosophila--genetics HEK293 Cells Humans Intracellular Space--genetics Karyopherins--genetics Neurodegenerative Diseases--genetics Peptides--genetics Protein Binding Protein Structure, Tertiary Protein Transport Proteins--chemistry Receptors, Cytoplasmic and Nuclear--genetics Trinucleotide Repeat Expansion Exportin 1 Protein