de Carné Trécesson, Sophie

Escape from p21-mediated oncogene-induced senescence leads to cell dedifferentiation and dependence on anti-apoptotic Bcl-xL and MCL1 proteins. [electronic resource] - The Journal of biological chemistry Apr 2011 - 12825-38 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M110.186437 doi


Cell Cycle Proteins--genetics
Cell Dedifferentiation
Cell Line, Tumor
Cell Proliferation
Cell Survival--genetics
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor Proteins--genetics
Cyclin-Dependent Kinase Inhibitor p21--genetics
Heterochromatin--genetics
Humans
Mutation, Missense
Myeloid Cell Leukemia Sequence 1 Protein
Oncogene Protein p21(ras)--genetics
Protein Serine-Threonine Kinases--genetics
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins B-raf--genetics
Proto-Oncogene Proteins c-bcl-2--genetics
Signal Transduction--genetics
Time Factors
Transcription, Genetic--genetics
Tumor Suppressor Protein p53--genetics
Up-Regulation--genetics
bcl-X Protein--genetics
cdc25 Phosphatases--genetics
Polo-Like Kinase 1