Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Feb 2011
- 2951-6 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1014863108 doi
Allosteric Regulation--physiology Animals Antithrombins--metabolism Calcium--metabolism Cell Line Dogs Epinephrine Flow Cytometry Luciferases P-Selectin--metabolism Peptide Fragments--metabolism Platelet Aggregation Protein Structure, Secondary--physiology Receptor, PAR-1--agonists Receptors, G-Protein-Coupled--metabolism Signal Transduction--physiology Thrombosis--metabolism