Nikam, Vandana S

Treprostinil inhibits the adhesion and differentiation of fibrocytes via the cyclic adenosine monophosphate-dependent and Ras-proximate protein-dependent inactivation of extracellular regulated kinase. [electronic resource] - American journal of respiratory cell and molecular biology Oct 2011 - 692-703 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1535-4989

10.1165/rcmb.2010-0240OC doi


Cell Adhesion--drug effects
Cell Differentiation--drug effects
Cells, Cultured
Cyclic AMP--metabolism
Cyclic AMP Response Element-Binding Protein--metabolism
Cyclic AMP-Dependent Protein Kinases--metabolism
Epoprostenol--analogs & derivatives
Extracellular Matrix--metabolism
Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors
Familial Primary Pulmonary Hypertension
Humans
Hypertension, Pulmonary--enzymology
Integrin alpha5--metabolism
Integrin beta1--metabolism
Leukocytes, Mononuclear--drug effects
Mutation
Phosphorylation
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-raf--metabolism
Receptors, Prostaglandin--metabolism
Signal Transduction--drug effects
Time Factors
Transfection
rap1 GTP-Binding Proteins--genetics
ras Proteins--metabolism