Kimachi, Keiichiro
Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis. [electronic resource]
- Naunyn-Schmiedeberg's archives of pharmacology Mar 2011
- 297-308 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
ISSN: 1432-1912
Standard No.: 10.1007/s00210-010-0596-4 doi
Subjects--Topical Terms: Acid Phosphatase--metabolism Animals Bone Marrow Cells--cytology Bone Resorption--metabolism Cell Differentiation--drug effects Cell Line, Tumor Cell Movement--drug effects Diphosphonates--pharmacology Diterpenes--pharmacology Dose-Response Relationship, Drug Gene Expression--drug effects I-kappa B Proteins--metabolism Imidazoles--pharmacology Isoenzymes--metabolism Macrophages--cytology Mice Mice, Inbred Strains NF-KappaB Inhibitor alpha NF-kappa B--metabolism Osteoclasts--cytology Phosphorylation--drug effects Protein Prenylation--drug effects RANK Ligand--pharmacology Receptor Activator of Nuclear Factor-kappa B--genetics Signal Transduction--drug effects Stem Cells--cytology Tartrate-Resistant Acid Phosphatase Transcription, Genetic--drug effects Tumor Necrosis Factor-alpha--pharmacology Up-Regulation--drug effects Zoledronic Acid