Curcumin diminishes the impacts of hyperglycemia on the activation of hepatic stellate cells by suppressing membrane translocation and gene expression of glucose transporter-2. [electronic resource]
- Molecular and cellular endocrinology Feb 2011
- 160-71 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1872-8057
10.1016/j.mce.2010.12.028 doi
Animals Cell Membrane--drug effects Cell Proliferation--drug effects Cells, Cultured Curcumin--pharmacology Dose-Response Relationship, Drug Gene Expression Regulation--drug effects Glucose--metabolism Glucose Transporter Type 2--genetics Glutamate-Cysteine Ligase--metabolism Glutathione--metabolism Hepatic Stellate Cells--drug effects Hyperglycemia--drug therapy Intracellular Space--drug effects Lipid Peroxidation--drug effects MAP Kinase Signaling System--drug effects Male Oxidative Stress--drug effects PPAR gamma--metabolism Protein Subunits--metabolism Protein Transport--drug effects Rats Rats, Sprague-Dawley Reactive Oxygen Species--metabolism Time Factors p38 Mitogen-Activated Protein Kinases--metabolism