Marchais-Oberwinkler, Sandrine <br/><br/>
New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.  [electronic resource] 

 -  Journal of medicinal chemistry  Jan 2011 
 - 534-47 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm1009082  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>17-Hydroxysteroid Dehydrogenases--antagonists & inhibitors<br/>Administration, Oral<br/>Animals<br/>Biological Availability<br/>Cell Line, Tumor<br/>Cell Membrane Permeability<br/>Cell-Free System<br/>Estrogen Receptor alpha--metabolism<br/>Estrogen Receptor beta--metabolism<br/>Estrogens--physiology<br/>Female<br/>Humans<br/>Liver--metabolism<br/>Male<br/>Microsomes--drug effects<br/>Molecular Mimicry<br/>Naphthols--chemical synthesis<br/>Phenols--chemical synthesis<br/>Placenta--enzymology<br/>Pregnancy<br/>Rats<br/>Rats, Sprague-Dawley<br/>Rats, Wistar<br/>Recombinant Proteins--antagonists & inhibitors<br/>Steroids--chemistry<br/>Structure-Activity Relationship