Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer. [electronic resource]
- Clinical cancer research : an official journal of the American Association for Cancer Research Dec 2010
- 6169-76 p. digital
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1557-3265
10.1158/1078-0432.CCR-10-0281 doi
Adult Aged Aged, 80 and over Algorithms Antineoplastic Agents, Alkylating--adverse effects Antineoplastic Combined Chemotherapy Protocols--adverse effects Aryl Hydrocarbon Hydroxylases--genetics Breast Neoplasms--drug therapy Carcinoma--drug therapy Cyclophosphamide--adverse effects Cytochrome P-450 CYP2B6 Cytochrome P-450 CYP3A--genetics Disease-Free Survival Female Glutathione S-Transferase pi--genetics Glutathione Transferase--genetics Humans Inactivation, Metabolic--genetics Metabolic Networks and Pathways--genetics Middle Aged North America Oxidoreductases, N-Demethylating--genetics Polymorphism, Genetic--physiology