TY - GEN AU - Schreck,Karisa C AU - Taylor,Pete AU - Marchionni,Luigi AU - Gopalakrishnan,Vidya AU - Bar,Eli E AU - Gaiano,Nicholas AU - Eberhart,Charles G TI - The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance SN - 1557-3265 PY - 2011///0404 KW - Antineoplastic Combined Chemotherapy Protocols KW - therapeutic use KW - Basic Helix-Loop-Helix Transcription Factors KW - metabolism KW - Brain Neoplasms KW - drug therapy KW - Cell Line, Tumor KW - Cyclic S-Oxides KW - administration & dosage KW - Drug Evaluation, Preclinical KW - Drug Resistance, Neoplasm KW - genetics KW - Gene Expression Regulation, Neoplastic KW - Glioblastoma KW - Hedgehog Proteins KW - Homeodomain Proteins KW - Humans KW - Receptors, Notch KW - Signal Transduction KW - Thiadiazoles KW - Transcription Factor HES-1 KW - Transcription Factors KW - U937 Cells KW - Veratrum Alkaloids KW - Zinc Finger Protein GLI1 N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/1078-0432.CCR-10-1624 ER -